LATEST NEWS older news

Sandia National Laboratories features our long-standing collaboration with Dr. Mike Kent studying the conformation of HIV Nef at the membrane.  Read the story here.

Small-angle X-ray scattering reveals how the shape of the Abl kinase changes upon activating mutations.
Read the ACS Editors' Choice article here.  

A collaboration with the Walensky Laboratory at DFCI/HMS uncovers allosteric regulation in the MCL-1 protein.    NSMB article    News & Views

As part of a special issue of JASMS honoring Brian Chait, we presented a comparison of the hydrogen-deuterium exchange of various versions of the HIV-1 Nef protein.  The article can be found here


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 15 years, we have applied HX MS to the study of over 100 proteins.