LATEST NEWS older news

A collaboration with Ken Westover at UT Southwestern uncovers inhibitor-specific perturbations in K-Ras.  Read the full article here.

Our collaborative study with Loren Walensky on the allosteric sensitization of BAX is published in Nature Chemical Biology.

Prof. Roxana Iacob is a guest columnist in LC-GC where she describes analysis of biosimilars with HDX MS.  Read the article here.

With the Waters Corp., we describe a new device for separations at -20 °C, published for Jim Jorgensen's birthday by the Journal of Chromatography A


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 16 years, we have applied HX MS to the study of hundreds of proteins.