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Unique affinity attachment allows for continuous flow deuterium labeling of captured proteins.                                                            Read more

In collaboration with Mike Ramsey's group at UNC-Chapel Hill, capillary electrophoresis separations for HX MS were demonstrated.
         Analytical Chemistry article

2015 Northeastern University Excellence in Teaching Award to Prof. Engen.
                    Read more here

Rane Harrison receives one of two 2015 travel awards from the Greater Boston Mass Spectrometry Discussion Group to attend the ASMS meeting in St. Louis, May 31-June 4


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 13 years, we have applied HX MS to the study of more than 75 proteins.