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all SH3 domains are the same. Despite sequence similarity,
and tertiary structure homology, the motions these domains
undergo in solution can be unique.
A new paper explores Tec family SH3 domains.
those using Q-Tof's with StepWave technology,
describes the optimal tuning of the StepWave in order to maximum deuterium recovery.
collaboration with Prof. Thomas Smithgall from the University of
Pittsburgh School of Medicine reveals how an inhibitor blocks
the HIV-1 Nef protein from activating the
cell kinase (Hck). read more