LATEST NEWS older news

Small-angle X-ray scattering reveals how the shape of the Abl kinase changes upon activating mutations.
   Read the ACS Editors' Choice article here.  

A collaboration with the Walensky Laboratory at DFCI/HMS uncovers allosteric regulation in the MCL-1 protein.    NSMB article    News & Views

As part of a special issue of JASMS honoring Brian Chait, we presented a comparison of the hydrogen-deuterium exchange of various versions of the HIV-1 Nef protein.  The article can be found here

Lab personnel receive awards:
       Tyler Kolfrat
  Wolfgang Goetzinger–Amgen Memorial
  Undergraduate Scholar Award


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 15 years, we have applied HX MS to the study of over 100 proteins.