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LATEST NEWS older news

The analytical aspects of HX MS are reviewed in a new article in the Annual Reviews of Analytical Chemistry.  A key attribute, replication, is further discussed in an editorial in Bioanalysis.      more

Unique affinity attachment allows for continuous flow deuterium labeling of captured proteins. Read more

In collaboration with Mike Ramsey's group at UNC-Chapel Hill, capillary electrophoresis separations for HX MS were demonstrated.
         Analytical Chemistry article


2015 Northeastern University Excellence in Teaching Award to Prof. Engen.
                    Read more here 

WELCOME


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.

 

We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 14 years, we have applied HX MS to the study of nearly 100 proteins.