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How do chaperones help proteins fold in vivo?  This was one of the questions addressed by a study recently published in Cell.    Read article

Greg Pirrone receives one of two 2014 travel awards from the Greater Boston Mass Spectrometry Discussion Group to attend the ASMS meeting in Baltimore, June 15-19.

Work recently published in the journal Structure shows that although tertiary structure may be known from crystal structure determination, protein dynamics can not be easily predicted. 
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The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 10 years, we have applied HX MS to the study of more than 65 proteins.