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Not all SH3 domains are the same.  Despite sequence similarity, and tertiary structure homology, the motions these domains undergo in solution can be unique.
A new paper explores Tec family SH3 domains.

For those using Q-Tof's with StepWave technology, this paper describes the optimal tuning of the StepWave in order to maximum deuterium recovery.

What makes mutants of the lipid transporting protein ApoA-I  turn into amyloids?  Read more here or here.

A collaboration with Prof. Thomas Smithgall from the University of Pittsburgh School of Medicine reveals how an inhibitor blocks the HIV-1 Nef protein from activating the hematopoetic cell kinase (Hck).            read more


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 14 years, we have applied HX MS to the study of nearly 100 proteins.