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A new survey of the applications of hydrogen / deuterium exchange mass spectrometry from 2012-2014 shows its widespread appeal.

Read the article in Analytical Chemistry issue "Fundamental and Applied Reviews in Analytical Chemistry 2015"

  Lab personnel receive awards:
  Mitch Gallerstein
       Early Honors Research Grant

In collaboration with Bristol-Myers Squibb, the interface between EGFR and adnectin was characterized with hydrogen exchange MS.  The results were published in JASMS.      More details


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 12 years, we have applied HX MS to the study of more than 75 proteins.