LATEST NEWS older news

Our collaborative study with Tom Smithgall on the HIV accessory protein Nef is published in the Journal of Molecular Biology.   Nef conformation changes during partner binding.  

We used HX MS in a multi-method study of the muscle remodeling protein GDF8, a collaboration with Scholar Rock and  Timothy Springer at Harvard Medical School & Boston Children's Hospital.   Article.   Press release.

Together with Amy Andreotti's lab at Iowa State University, we describe the inner workings of Bruton's tyrosine kinase (BTK), a kinase essential for B and mast cell function.  Full article here.  Preview here.

A collaboration with Ken Westover at UT Southwestern uncovers inhibitor-specific perturbations in K-Ras. Read the full article here.


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 17 years, we have applied HX MS to the study of hundreds of proteins.