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Hydrogen exchange MS shows how a covalent inhibitor developed by the Gray Laboratory at the Dana-Farber Cancer Institute & Harvard Medical School traps the oncogenic K-Ras G12C mutant in an inactive conformation. More details
In collaboration with Aileron Therapeutics, we illustrate how hydrogen exchange mass spectrometry can be used to measure the stability and conformational dynamics of stapled peptides. The HX MS results predict pharmacokinetic properties. More details
New results obtained in collaboration with Biogen-Idec show that antibody aggregation is complicated. What causes one antibody to form dimers is not necessarily the cause for others. Analytical measurements should be applied to each case. More details