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Work recently published in the journal Structure shows that although tertiary structure may be known from crystal structure determination, protein dynamics can not be easily predicted. Proteins with highly similar shape may move and flex differently in solution and this could have an impact on function. More details
2014 cover story in BioPharm International on higher order
structure determination for protein therapeutics, including
comments from Prof. Engen on the use of HDX-MS.
BioPharm International website Lexicon
Hydrogen exchange MS shows how peptide binding affects a transmembrane 95 kDa glycosylated protein embedded in a phospolipid nanodisc. Such studies will make conformational analyses of many membrane proteins and protein complexes feasible. More details