LATEST NEWS older news

Lab personnel receive awards:
  Mitch Gallerstein
       Early Honors Research Grant

In collaboration with Bristol-Myers Squibb, the interface between EGFR and adnectin was characterized with hydrogen exchange MS.  The results will soon appear in JASMS.      More details

How do chaperones help proteins fold in vivo?  This was one of the questions addressed by a study recently published in Cell.    Read article


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 10 years, we have applied HX MS to the study of more than 65 proteins.