LATEST NEWS older news

Isaac Kresse awarded a Barry Goldwater Scholarhip.  Read more about Isaac and the other Northeastern University winners.

Our paper about how to study protein complexes
by HX MS is published.  Read the full article here.

Our collaborative study with Tom Smithgall on the HIV accessory protein Nef is published in the Journal of Molecular Biology.   Nef conformation changes during partner binding.  

We used HX MS in a multi-method study of the muscle remodeling protein GDF8, a collaboration with Scholar Rock and  Timothy Springer at Harvard Medical School & Boston Children's Hospital.   Article.   Press release.


The laboratory of John R. Engen at Northeastern University performs research at the interface of Analytical Chemistry, Biochemistry & Structural Biology.


We use hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

In the past 17 years, we have applied HX MS to the study of hundreds of proteins.