Fall 2017

Together with Amy Andreotti's lab at Iowa State University, we describe the inner workings of Bruton's tyrosine kinase (BTK), a kinase essential for B and mast cell function.  Full article here.  Preview here.

Fall 2017

A collaboration with Ken Westover at UT Southwestern uncovers inhibitor-specific perturbations in K-Ras. Read the full article here.

September 2017

Our collaborative study with Loren Walensky on the allosteric sensitization of BAX is published in Nature Chemical Biology.

Summer 2017

Prof. Roxana Iacob is a guest columnist in LC-GC where she describes analysis of biosimilars with HDX MS.  Read the article here.

Summer 2017

With the Waters Corp., we describe a new device for separations at -20 °C, published for Jim Jorgensen's birthday by the Journal of Chromatography A

May 2017

Chris Wilson receives one of two 2017 travel awards from the Greater Boston Mass Spectrometry Discussion Group to attend the ASMS meeting in Indianapolis, June 4-8


Spring 2017

Prof. Engen named a Distinguished Professor of Chemistry & Chemical Biology.  Read more here.

November 2016

A collaboration with Kenneth Westover at UT Southwestern uncovers familial relationships in Ras-family proteins.  Read the full article here.

September 2016

Northeastern University College of Science explains our recent partnership with Prof. Timothy Springer of Children's Hospital Boston. News story.

Fall 2016

A collaboration with the Walensky Laboratory at DFCI/HMS uncovers allosteric regulation in the MCL-1 protein.    NSMB article    News & Views

August 2016

Sandia National Laboratories features our long-standing collaboration with Dr. Mike Kent studying the conformation of HIV Nef at the membrane.  Read the story here.

Summer 2016

As part of a special issue of JASMS honoring Brian Chait, we presented a comparison of the hydrogen-deuterium exchange of various versions of the HIV-1 Nef protein.  The article can be found here


June 2016

Small-angle X-ray scattering reveals how the shape of the Abl kinase changes upon activating mutations.
Read the ACS Editors' Choice article here.  

May 2016

Lab personnel receive awards:
       Tyler Kolfrat
  Wolfgang Goetzinger–Amgen Memorial Undergraduate Scholar Award

Spring 2016

HX MS contributes to our understanding of how substrates are recognized and then degraded by the proteasome. Read the paper here 

April 2016

Not all SH3 domains are the same.  Despite sequence similarity, and tertiary structure homology, the motions these domains undergo in solution can be unique.
A new paper explores Tec family SH3 domains.

April 2016

A new paper describes the optimal tuning of a StepWave in order to maximum deuterium recovery.

January 2016

What makes mutants of the lipid transporting protein ApoA-I  turn into amyloids?
Read more here or here.